Further improvements are needed in efficacy assessment methods. Although scale assessment has been used for many years, the limitations in symptom assessment cannot be ignored. Currently, most scale assessments can only assess the improvement of a certain aspect of clinical symptoms. Furthermore, the scales are prone to human error. The application of computer analysis of EEG data in other fields Beaty et al. MRI and EEG, as objective examination methods, are sensitive to the changes in brain structure and function.
Additional Table 1 : Completed and recruiting clinical trials of stem cells therapy for CP. Additional Table 2 : Other clinical trials of stem cells therapy for CP. Additional Table 3 : Published clinical trials of stem cell therapy for CP. Additional Figure 1 : The type of CP patients enrolled in clinical trials.
Additional Figure 2 : The administration routes of stem cell therapy for CP. Copyright license agreement: The Copyright License Agreement has been signed by all authors before publication. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. National Center for Biotechnology Information , U. Journal List Neural Regen Res v.
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This article has been cited by other articles in PMC. Additional Figure 2: The administration routes of stem cell therapy for CP. Abstract Cerebral palsy is the most common disease in children associated with lifelong disability in many countries. Keywords: adverse events, brain, cell transplantation, central nervous system, cerebral palsy, clinical trials, plasticity, regeneration, stem cell.
Introduction Cerebral palsy CP is a group of permanent disorders of the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, communication and behavior, by epilepsy, and by secondary musculoskeletal problems Rosenbaum et al.
Additional Table 1 Completed and recruiting clinical trials of stem cells therapy for CP. Open in a separate window. Additional Table 2 Other clinical trials of stem cells therapy for CP. Additional Table 3 Published clinical trials of stem cell therapy for CP. The improvement in intelligence quotient was less obvious. Min et al. Types of Stem Cells Transplanted for the Treatment of Cerebral Palsy Despite the abundance of stem cell sources, the stem cells used in these clinical trials were mainly derived from the following five tissues: bone marrow Sharma et al.
Figure 1. The stem cell types used in clinical trials for cerebral palsy. Administration routes CP patients participating in stem cell clinical trials can receive stem cell transplantation in a variety of ways Figure 2. Figure 2. The common administration routes for cerebral palsy patients in stem cell therapy. Dosage and course Currently, there is no unified standard for the dosage and transplantation of stem cells.
Rehabilitation program Most patients had received rehabilitation for at least 3 months before stem cell therapy, but without obvious improvement. Typical drug Typical drugs used for CP have limited therapeutic effect and often need repeated administration to maintain effectiveness.
Adverse events In clinical trials, adverse events are of great concern and have been documented in all studies Additional Table 3. Efficacy Gross motor function All stem cell therapies have produced improvements in gross motor function, but the improvements have varied. Fine motor function In contrast to the significant gross motor function improvements, fine motor changes are not as widespread. Muscle tone Muscle tension is a common problem for many CP patients.
Cognition Improvements in cognition with stem cell therapy have been reported in multiple clinical trials. Others In addition to the above symptoms, many other improvements have been reported in clinical trials.
Mechanisms Underlying the Effectiveness of Stem Cell Therapy for Cerebral Palsy It is well-known that stem cells have the ability to differentiate, and under appropriate conditions, become any type of cell in the human body. Challenges in the Future Application of Stem Cell Therapy for Cerebral Palsy With the increase in the number of clinical studies, stem cells are expected to be marketed successively in the near future, bringing new options for the treatment of CP.
Additional files: Additional Table 1 : Completed and recruiting clinical trials of stem cells therapy for CP. Additional Figure 1 The type of CP patients enrolled in clinical trials. Click here to view.
Additional Figure 2 The administration routes of stem cell therapy for CP. References 1. Disabil Rehabil. Cell transplantation therapy for spinal cord injury. Nat Neurosci. Communication dynamics in complex brain networks. Nat Rev Neurosci. Creative cognition and brain network dynamics. Trends Cogn Sci. Cell therapy for neonatal hypoxia-ischemia and cerebral palsy. Ann Neurol. Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering. J Cereb Blood Flow Metab.
A critical evaluation of current concepts in cerebral palsy. Physiology Bethesda ; 34 — Autologous haematopoietic stem cell transplantation for neurological diseases. J Neurol Neurosurg Psychiatry. Update on stem cell therapy for cerebral palsy. Expert Opin Biol Ther. Neural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy.
J Transl Med. Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: a randomized controlled clinical trial. Cell Transplant. Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury.
Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells. J Tissue Eng Regen Med. Eur J Cell Biol. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement. PLoS One. Am J Transl Res. Duncan T, Valenzuela M. Stem Cell Res Ther. Stem cell treatment and cerebral palsy: Systemic review and meta-analysis.
World J Stem Cells. Current proceedings of cerebral palsy. The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine. Cell Prolif 44 Suppl. The route by which intranasally delivered stem cells enter the central nervous system. Cerebral palsy. Nat Rev Dis Primers. Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: a randomized, controlled trial. Transl Neurodegener. Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children.
Huang L, Zhang L. Neural stem cell therapies and hypoxic-ischemic brain injury. Prog Neurobiol. A randomized, placebo-controlled trial of human umbilical cord blood mesenchymal stem cell infusion for children with cerebral palsy. Stem cells and cell-based therapies for cerebral palsy: a call for rigor. Pediatr Res. A new approach to cerebral palsy treatment: discussion of the effective components of umbilical cord blood and its mechanisms of action.
Jin J. Stem Cell Treatments. Dev Med Child Neurol. The role of stem cells in the treatment of cerebral palsy: a review. Mol Neurobiol. Int J Mol Sci. The complex aetiology of cerebral palsy. Nat Rev Neurol. Exogenous neural stem cell transplantation for cerebral ischemia. Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy.
Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev. Effects of neural progenitor cell transplantation in children with severe cerebral palsy. Cerebral palsy: causes, pathways, and the role of genetic variants. Am J Obstet Gynecol. Safety and tolerability of intrathecal delivery of autologous bone marrow nucleated cells in children with cerebral palsy: an open-label phase I trial.
Stem cells therapy for ALS. Treating problem gambling samples with cognitive behavioural therapy and mindfulness-based interventions: a clinical trial.
The CHW delivered home visit intervention includes stress …. This study has 7 visits and can be completed in as little as 9 days or up to 7 weeks. A Phase 3, Multi-site, randomized, mixed-blind, parallel-group treatment withdrawl and re-treatment study of the efficacy and safety of 2 oral doses of CP , in Subjects with Moderate to Severe. Many people with migraines receive little relief from over-the. Herpes Cold Sore. The purpose of this research is to understand how flavor affects young adult's perceptions of little cigar or cigarillo use.
It will be protected with a passcode Generate session link. Access your activity on CenterWatch with a private link and passcode. Share Passcode: Copy to clipboard. Cerebral Palsy Clinical Trials A listing of Cerebral Palsy medical research trials actively recruiting patient volunteers. Please select a valid location from the dropdown.
Filter By Clear all Advanced. Male only 28 Female only Any Reset Apply. I am looking for. I am looking for botulinum toxin. I am looking for botulinum toxin type a. National Institutes of Health Researchers want to find out if DA gene variations cause some of this variability. All primary and secondary efficacy outcomes rely on blinded assessments at baseline, end of treatment, and 6 mos post-treatment.
Exploratory outcomes and supplemental clinical measures may provide valuable additional data about development and health in this sample of children with PAS.
Neonatal seizures due to brain injury acute symptomatic seizures are associated with high risk of neurodevelopmental disability in infancy. Although prognosis in early childhood is a critical question for parents and providers, outcomes beyond infancy are largely unknown. Further, parents of infants with neonatal seizures are at risk for mental health disorders, which can undermine their ability to care for a child with medical complexity and may contribute to impaired child development.
Participants will be evaluated using developmental questionnaires and in-person neurodevelopmental testing. Parent well-being will be assessed at each time point. Pain in children and adolescents with cerebral palsy CP is a significant health challenge that so far has received too little attention.
We lack knowledge on how pain is experienced, its consequences and of perceived support in managing pain. The overarching aim of the CPPain-program is to reduce pain experience, pain interference e. CPPain has a prospective cohort comparative design and will include before- and after measurements and process evaluation of a nested intervention. This protocol concerns qualitative and quantitative data collection for the baseline of the CPPain program.
The aim of the baseline data collection is to contribute in-depth knowledge of the pain burden in children and adolescents with CP. This knowledge is required to develop targeted pain-diminishing interventions in this vulnerable group of children with a high burden of challenges related to their chronic disease. In the next step, nested intervention will be co-created with children and adolescents with CP, their parents as well as health care professionals, and other professional caregivers involved in or responsible for management of pain based on existing research and baseline findings.
Cerebral palsy CP is a common childhood-onset disability associated with motor and cognitive impairments, however most research is focused on motor outcomes.
The aim of this study is to determine the effects of Amantadine, a dopaminergic agonist, on cognitive function in adolescents and adults with CP. A significant deficit affecting nearly half of children with hemiplegia is visual-motor integration, or eye-hand coordination. Children have difficulties integrating visual and motor information to effectively plan and execute movements.
Visual-motor impairments are detrimental because they affect accuracy of reaching and grasping, which are movements involved in feeding, writing, and sports participation, among many other daily life activities.
Although paper-and-pencil and touchscreen computer assessments exist, these fail to evaluate impairments under realistic, 3D conditions. This assessment barrier leads to significant gaps in knowledge the influence of these impairments on children's performance of functional activities.
The purpose of this study is to evaluate low-cost HMD-VR as a realistic assessment tool for visual-motor integration deficits in children with hemiplegia. The long-term goals of our research program are to: 1 Inform clinical decision-making practices by providing families and clinicians with precise, accurate information about children's abilities; and 2 Generate new knowledge about visual-motor integration impairments to enhance the effectiveness of both virtual and conventional rehabilitation interventions.
This study aims to examine how effective seated Zoom exercise classes are for a person with CNI for addressing cardiovascular health, physical wellness and quality of life. The entire process, including screening and consenting, will be done via Zoom and Redcap, potentially providing a blueprint for the future studies. This process can enable participants to participate in studies with minimal inconvenience, expense and effort of traveling for the consent process. A recent systematic review found that therapeutic interventions that apply principles of motor learning with intense practice improve functional upper extremity movement in children with unilateral CP.
Evidence of efficacy for any treatment approach aimed at improving motor function in bilateral CP the most prevalent form is lacking. Preliminary investigation suggests that intensive 90 hours goal-directed, task-specific training provided in a 3-week day camp format can improve functional movement of both the upper UE and lower extremity LE and postural control in children with Bilateral CP. Implementing the dosing schedule of this promising intensive approach in a hospital setting requires innovative resource allocation space and staff ; thus, examining alternative delivery models is imperative.
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